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杨红

   教授,博士生导师。教育部“新世纪优秀人才支持计划”项目获得者,辽宁省特聘教授。主要研究领域为水盐代谢与消化系统疾病机制和药物高通量筛选研究。
一、学习经历
2009.11-2010.5 德国慕尼黑大学(LMU)药理学与化学系,高级访问学者
2002.4-2003.5 美国加州大学旧金山医学院(UCSF)医学系,访问学者
2001.8-2003.10 吉林大学基础医学院,博士后
1998.9-2001.7 东北师范大学细胞与遗传学研究所,博士生,获理学博士学位
1992.9-1995.7 吉林大学研究生院生物化学专业,硕士生,获理学硕士学位
1987.9-1992.7 吉林大学分子生物学系生物化学专业,本科生,获理学学士学位

二、工作经历
2006.8-至今 新万博体育app,博士生导师
2004.8-至今 新万博体育app,教授
2001.12-2004.7 东北师范大学遗传与细胞研究所,副教授
1995.7-2001.12 东北师范大学遗传与细胞研究所,助教、讲师

研究成果

(一)近年来主持的主要科研项目

  1. 科技部重大新药创制“高端制剂、新型辅料品种及共性关键技术研发”课题“中药雾化吸入制剂吸入给药的关键技术研究”(2017ZX09201-002-007)分课题负责人,50.02万元,2017.1—2020.12
  2. 国家自然科学基金面上项目“CFTR选择性抑制剂的发现及其在上皮液体分泌研究中的应用”(No. 81473265),65万元,2015.1—2018.12
  3. 辽宁省特聘教授计划项目,100万元,2015.12-2018.12
  4. 国家自然科学基金面上项目“CFTR氯离子通道在慢性胰腺炎发病机理及治疗中的作用”(No. 30973577 ),32万元,2010.1-2012.12
  5. 科技部国家重点基础研究发展计划项目(973项目)“脑血管疾病发生和防治的基础研究”课题“新的天然活性化合物在脑卒中研究与防治中的应用”(2009CB521908)课题骨干,60万元,2009-2013
  6. 美国囊性纤维化基金会药物发现专项(项目号MA08XX0),“Discovery of Natural compounds F508-CFTR misprocessing correctors from Chinese medicinal herbs”,Cystic Fibrosis Foundation, USA. co-PI,28万美元,2008-2010
  7. 教育部“新世纪优秀人才支持计划”项目 “cAMP激活的氯离子通道在遗传性多囊肾病发病机理中的作用”(NCET-07-0406),50万元,2007-2009
  8. 国家自然科学基金面上项目“CFTR氯离子通道在常染色体显性多囊肾病发病机理中的作用”(No. 30570864),26万元,2006.1-2008.12
  9. 国家自然科学基金面上项目“CLC-7 氯离子通道小分子调节剂的高通量筛选及应用”(No. 30470405),21万元,2005.1-2007.12
  10. 高等学校博士学科点专项科研基金项目(博导类)“特异性CFTR氯离子通道抑制剂的发现及其作用机制研究”(20112136110002),12万元,2012.1—2014.12
  11. 辽宁省“高等学校优秀人才支持计划”项目“氯离子通道蛋白CFTR在ADPKD中的作用”(2006R33),10万元,2007.1-2009.12

(二)发表的SCI学术论文(*为通讯作者)

  1. Yu B, Jiang Y, Zhang B, Yang H*, Ma T*. Resveratrol dimer trans-ε-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel. Pharmacol Res. 2018 Mar;129:453-461.
  2. Yang H, Ma T*. Luminally Acting Agents for Constipation Treatment: A Review Based on Literatures and Patents. Front Pharmacol. 2017 Jun 30;8:418.
  3. Jiang Y, Zhang G, Yan D, Yang H*, Ye Z*, Ma T. Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor. Evid Based Complement Alternat Med. Volume 2017, Article ID 9425963.
  4. Yu B, Zhang G, Jin L, Zhang B, Yan D, Yang H*, Ye Z*, Ma T. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489.
  5. Yu B, Jiang Y, Jin L, Ma T*, Yang H*. Role of Quercetin in Modulating Chloride Transport in the Intestine. Front Physiol. 2016 Nov 23;7:549.
  6. Jiang Y, Yu B, Yang H*, Ma T*. Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea. Front Pharmacol. 2016 Aug 23;7:270.
  7. Jiang Y, Yu B, Fang F, Cao H, Ma T, Yang H*. Modulation of chloride channel functions by the plant lignan compounds kobusin and eudesmin. Front Plant Sci. 2015 Nov 25;6:1041.
  8. Yu B, Jiang Y, Liu Y, Ma T*, Yang H*. Chloride channel inhibition by ethanol extract from Bistortae rhizoma prevents secretory diarrhea. Bangladesh J Pharmacol 2015; 10: 00-00.
  9. Yang H*, Ma T. F508del-cystic fibrosis transmembrane regulator correctors for treatment of cystic fibrosis: a patent review. Expert Opin Ther Pat. 2015 Sep;25(9):991-1002.
  10. Chen L, Yu B, Zhang Y, Gao X, Zhu L, Ma T, Yang H*. Bioactivity-guided Fractionation of an Antidiarrheal Chinese Herb Rhodiola kirilowii (Regel) Maxim Reveals (-)epicatechin-3-gallate and (-)epigallocatechin-3-gallate as Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator. PLoS One. 2015 Mar 6;10(3):e0119122.
  11. Luan J, Zhang Y, Yang S, Wang X, Yu B, Yang H*. Oridonin: A small molecule inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR) isolated from traditional Chinese medicine. Fitoterapia. 2015 Jan;100:88-94.
  12. Jiang Y, Yu B, Wang X, Sui Y, Zhang Y, Yang S, Yang H*, Ma T. Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin. Fitoterapia. 2014 Dec;99:284-291.
  13. Zhang Y, Yu B, Sui Y, Gao X, Yang H*, Ma T*. Identification of resveratrol oligomers as inhibitors of cystic fibrosis transmembrane conductance regulator by high-throughput screening of natural products from chinese medicinal plants. PLoS One. 2014 Apr 8;9(4):e94302.
  14. Yu B, Zhang Y, Sui Y, Yang S, Luan J, Wang X, Ma T, Yang H*. Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrol. Pharmazie. 2013 Nov;68(11):877-881.
  15. Yang S, Yu B, Sui Y, Zhang Y, Luan J, Wang X, Hwang T, Ma T, Yang H*. CFTR chloride channel is a molecular target of the natural cancer preventive agent resveratrol. PHARMAZIE, 2013, 68(9): 772776.
  16. Wang X, Zhang Y, Yu B, Yang S, Luan J, Yang H*. Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and F508 mutant CFTR chloride channel. J Asian Nat Prod Res. 2013 Aug;15(8):855-866.
  17. Zhou Y, Bi Y , Yang C, Yang J, Jiang Y, Meng F, Yu B, Khan M, Ma T, Yang H*. Magnolol Induces Apoptosis in MCF-7 Human Breast Cancer Cells through G2/M Phase Arrest and Caspase-independent Pathway. PHARMAZIE, 2013, 68(9): 755762.
  18. Meng F, Yang J, Yang C, Jiang Y, Zhou Y, Yu B, Khan M, Yang H*. Vitexicarpin Induces Apoptosis in Human Prostate Carcinoma PC-3 Cells through G2/M Phase Arrest. Asian Pac J Cancer Prev. 2012, 13(12), 6369-6374.
  19. Jiang Y, Yang J, Yang C, Meng F, Zhou Y, Yu B, Khan M, Yang H*. Vitamin K4 Induce Tumor Cytotoxicity in Human Prostate Carcinoma PC-3 Cells via the Mitochondria-related Apoptotic Pathway. PHARMAZIE, 2013, 68: 442448.
  20. Meng X, Wang Y, Zheng X, Liu C, Su B, Nie H, Zhao B, Zhao X, Yang H*. shRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and metastasis. Lung Cancer. 2012,77(1):24-30.
  21. Rasul A, Yu B, Yang LF, Ali M, Khan M, Ma T, Yang H*. Induction of Mitochondria-mediated Apoptosis in Human Gastric Adenocarcinoma SGC-7901 Cells by Kuraridin and Nor-kurarinone Isolated from Sophora Flavescens. Asian Pac J Cancer Prev. 2011,12 (10):2499-2504.
  22. Rasul A, Khan M, Yu B, Ma T, Yang H*. Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells. Asian Pac J Cancer Prev. 2011,12(5):1219-1223.
  23. Li K, Diao Y, Zhang H, Wang S, Zhang Z, Yu B, Huang S, Yang H*. Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats. BMC Complement Altern Med. 2011,11(1):86.
  24. Yang H*, Xu L, Sui Y, Liu X, He C, Fang R, Liu J, Hao F, Ma T. Stimulation of airway and intestinal mucosal secretion by natural coumarin CFTR activators. Front Pharmacol. 2011;2:52.
  25. Yang H*, Xu LN, He CY, Liu X, Fang RY, Ma TH. CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives. Acta Pharmacol Sin .2011, 32(6): 834-839.
  26. Jin L, Liu X, Sun Y, Lin S, Zhou N, Xu L, Yu B, Hou S, Yang H*. Activation of CFTR-mediate Cl- transport by Magnolin. Chem. Res. Chinese U. 2008, 24 (2): 187-191.
  27. Liu X, Guan L, He C, Zhang X, Xu L, Shang D, Ma T, Yang H*. Natural Compound Curcumin—a Channel Potentiator Rather Than a Corrector of the Defective Intracellular Processing of F508 Mutant Cystic Fibrosis Transmembrane Conductance Regulator. Chem. Res. Chinese U. 2008, 24 (2): 200-203.
  28. Hao L, Liu X, Xu L, Zhu N, Lin S, Hou S, Zhou N, Shi D, Shang D, Ma T, Yang H*. Natural Compound Curcumin Corrects the Gating Defect of G551DMutant Cystic Fibrosis Transmembrane Conductance Regulator. Chem. Res. Chinese U. 2008, 24 (1): 92-95.
  29. Liu J, Liu L, Wang S, Xu L, Yu B, Lin, S, Hou S, Zhou N, Jin L, Yang H*. Dictamine stimulates cystic fibrosis transmembrane conductance regulator Cl- transport. Chem. Res. Chinese U. 2007, 23(5): 554-557.
  30. Jin S, Liu Y, Xu L, Jiang Y, Wang Y, Yang B, Yang H*, Ma T. Cloning and characterization of a porcine aquaporin 1 water channel expressed extensively in gastrointestinal system. World J Gastroenterol. 2006, 12(7):1092-1097.
  31. Shi L, Xu L, Hou S, Lin S, Yang H* and Ma T. Activation effect of carthartic natural compound rhein to CFTR chloride channel. Chem. Res. Chinese U. 2006, 22(3): 312-314.
  32. Wang Y, Zhao L, He C, Xu L, Yang H*. Activation of G551D-CFTR by Bicyclooctane Compounds Is cAMP-dependent and Exhibits Low Sensitivity to Thiazolidinone CFTR Inhibitor CFTRinh-172. Chem. Res. Chinese U. 2005, 21(2): 183-186.
  33. He C, Zhao L, Liu Y, Xu L, Shang D, Yang H*. A Class of High-affinity Bicyclooctane G551D-CFTR Activators Identified by High Throughput Screening. Chem. Res. Chinese U. 2004, 20(6): 738-742.
  34. Zhao L, He C, Zhou H, Zhou J, Yang H*. A high-affinity bicyclooctane activator of G551D-CFTR cloride channel identified by high throughput screening. Chem. Res. Chinese U. 2004, 20(6): 743-746.
  35. He C, Zhang H, Su Z, Zhou J, Yang H*, Ma T. Synthesis and characterization of a small molecule thiazolidinone CFTR chloride channel inhibitor. Chem. Res. Chinese U. 2004, 20(3): 334-337.
  36. Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. Nanomolar Affinity Small Molecule Correctors of Defective {Delta}F508-CFTR Chloride Channel Gating. J Biol Chem. 2003, 278(37):35079-35085.
  37. Zheng X, Wang Y, Liu B, Liu C, Liu D, Zhu J, Yang C, Yan J, Liao X, Meng X*, Yang H. Bmi-1-shRNA Inhibits the Proliferation of Lung Adenocarcinoma Cells by Blocking the G1/S Phase Through Decreasing Cyclin D1 and Increasing p21/p27 Levels. Nucleic Acid Ther. 2014 Jun;24(3):210-216.
  38. Ma T, Gao H, Fang X, Yang H. Water channel proteins in the peripheral nervous system in health and disease. Mol Aspects Med. 2012,33(5-6):605-611.
  39. Rasul A, Yu B, Zhong L, Khan M, Yang H, Ma T. Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. Oncol Rep. 2012, 27(5): 1481-1487.
  40. Khan M, Yu B, Rasul A, Al Shawi A, Yi F, Yang H, Ma T. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. Evid Based Complement Alternat Med. 2012; 2012:703034.
  41. Rasul A, Yu B, Khan M, Zhang K, Iqbal F, Ma T, Yang H. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol. 2011 ,40(4):1153-1161.
  42. Zhu N, Feng X, He C, Gao H, Yang L, Ma Q, Guo L, Qiao Y, Yang H, Ma T. Defective macrophage function in aquaporin-3 deficiency. FASEB J. 2011,25(12):4233-4239.
  43. Ma T, Gao H, Fang X, Yang H. Expression and function of aquaporins in peripheral nervous system. Acta Pharmacol Sin .2011, 32(6): 711-715.
  44. Hao F, Yi F, Zhang D, Ning Y, Sui Y, Su W, Feng X, Yang H, Ma T*. Identification of herbal compound Imperatorin with adverse effects on ANO1 and CFTR chloride channels. Chem. Res. Chinese U. 2011, 27 (3) :461-463.
  45. Jiang Y, Su B, Meng X*, Liu C, Liu B, Liu D, Fan Y, Yang H. Effect of siRNA-mediated silencing of Bmi-1 gene expression on HeLa cells. Cancer Sci. 2010,101(2):379-386.
  46. Liu X, Ge H, Zhao X, Hou T, Sun J, Yang J, He C*, Yang H. Direct Activation of CFTR Chloride Channel by Natural Compound Theophylline. Chem. Res. Chinese U. 2009, 25 (6): 887-890.
  47. Gao H, He C, Fang X, Hou X, Feng X, Yang H, Zhao X, and Ma T*. Localization of aquaporin-1 water channel in glial cells of the human peripheral nervous system. Glia. 2006,53(7):783-787.
  48. Wang F, Feng X, Li Y, Yang H, Ma T*. Aquaporins as potential drug targets. Acta Pharmacologica Sinica. 2006, 27(4):395-401.
  49. Zhao X, Hou T, Ge H, Sun J, Yang H ,Ma T*. Activation of CFTR-mediated Cl Transport by Capsaicinoids in Cell Culture Model. Chem. Res. Chinese U. 2009, 25(2):220-223.
  50. Liu Y, Wang Y, Jiang Y, Zhu N, Liang H, Xu L, Feng X, Yang H, Ma T*. Mild Processing Defect of Porcine F508-CFTR Suggests that F508 Pigs May Not Develop Cystic Fibrosis Disease. Biochem. Biophys. Res. Commun. 2008,15(373): 113-118.
  51. Xu L, Na W, Liu X, Hou S, Lin S, Yang H, Ma T*. Identification Of Natural coumarin compounds that rescue defective F508-CFTR chloride channel gating. Clinical and Experimental Pharmacology and Physiology,2008, 35(8):878-883.
  52. Li Y, Feng X, Yang H, Ma T*. Expression of aquaporin-1 in SMMC-7221 liver carcinoma cells promotes cell migration. Chinese Science Bulletin. 2006, 51(20):2466-2471.
  53. Li M, Jiang Y, Wang S, Li Y, Wang F, Hou X, Yang H, Ma T*. cDNA Cloning, Prokaryotic and Eukaryotic Expression and Characterization of Porcine Leukemia Inhibitory Factor. Chem. Res. Chinese U. 2006, 22(2): 145-149.
  54. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain.Bioorg Med Chem. 2003 ,11(18):4113-4120.
  55. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS*. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002, 110(11):1651-1658.
  56. Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS*. High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J Biol Chem. 2002,277(40):37235-37241.

(三)发明专利

  1. “嘧啶(硫)酮类化合物在制药中的应用”。发明人:麻彤辉,杨红。专利号ZL200510017135.X。授权时间:2009年2月15日。
  2. 基因工程新药——“重组人粒细胞集落刺激因子”,2000年通过国家药品监督管理局审评鉴定,获得国家新药证书(国药证字(2002)S-38号),主要完成人。
  3. “重组人粒细胞集落刺激因子”,2002年通过教育部鉴定,第三完成人。
  4. “纤溶酶原的结构与功能”,2004年通过吉林省科技厅鉴定,第二完成人。
  5. “基因工程新药——重组人粒细胞集落刺激因子的研制”项目,获2002年度吉林省科技进步二等奖,第三完成人。

荣誉

    1. 教育部“新世纪优秀人才支持计划”项目获得者
    2. 辽宁省特聘教授
    3. 辽宁省“百千万人才工程”百人层次人选
    4. 辽宁省“高等学校优秀人才支持计划”项目获得者
    5. 辽宁省优秀青年骨干教师

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大连市甘井子区柳树南街1号、辽宁师范大学西山校区,新万博体育app | 邮编:116081
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信 箱:hyang@nenu.edu.cn;hyanglnnu@gmail.com