首页 > 师资队伍 > 研究生导师

麻彤辉

性别:男
民族:回族
出生年月:1963年7月16日
单位:吉林大学第二医院中心实验室
地址:吉林省长春市自强街265号,邮编130041
电话(办):0431-88796667
手机:18686347968;13943178166
信箱:math.jlu@gmail.com;tonghuima@jlu.edu.cn

个人情况综述

     国家杰出青年基金获得者、教育部第七批“长江学者奖励计划”特聘教授、吉林大学唐敖庆特聘教授。长期从事膜蛋白结构与功能和高通量筛选药物发现研究,在国际上首先建立了水通道基因敲除小鼠模型并进行了大量水通道基因功能的创新性研究,建立了国际领先的基于高通量筛选的中药天然产物化学遗传学平台,在水通道蛋白基因功能和氯离子通道小分子药物发现方面做出重要贡献。目前主要研究方向是细胞膜通道基因功能与药物发现。主持了国家杰出青年基金、国家自然科学基金、科技部国家重点基础研究发展计划项目(973)课题、美国囊性纤维化基金会药物发现项目等。在SCI杂志上发表研究论文100余篇,影响因子总和超过430,被SCI源期刊引用7200余次。2005年享受国务院政府特殊津贴。
一、主要学习简历(含国内外访学):
1979.9-1984.7,白求恩医科大学医学系,本科,获学士学位。
1984.9-1987.7,白求恩医科大学基础医学院,研究生,获硕士学位。
1991.1-1994.7,白求恩医科大学基础医学院与美国加州大学旧金山医学院(UCSF)联合培养,研究生,获博士学位。
二、主要工作简历
1991.1-1996.1,美国加州大学旧金山医学院(UCSF),博士后。
1996.1-2001.2,美国加州大学旧金山医学院(UCSF),助理研究员。
2001.2-2003.3,美国加州大学旧金山医学院(UCSF),助理教授。
2003.3-2009.6,东北师范大学膜通道实验室,主任,教授。
2009.7-2011.12,吉林大学第二医院中心实验室,主任,教授。
2010.10-现在,吉林省重大疾病分子与化学遗传学重点实验室,主任。
2012.1-现在,吉林大学第二医院院长助理,转化医学中心主任。
三、社会学
《Frontiers in Ethnopharmacology》杂志副主编
《生物化学与生物物理进展》杂志编委。
长春市药学会会员
四、荣誉
教育部“长江学者奖励计划”特聘教授
“新世纪百千万人才工程”国家级人选
享受国务院政府特殊津贴
吉林大学唐敖庆特聘教授
吉林省高级专家
吉林省优秀专业技术人才
长春市第四批有突出贡献专家
五、主持的主要科研项目

  1. 973项目课题,“卵巢局部因子在卵泡发育及排卵障碍中的作用机制”(课题号2012CB944702),210万元人民币,2012年-2016年,课题骨干。
  2. 国家自然科学基金,“选择性TMEM16A钙激活氯离子通道天然小分子抑制剂的发现及其作用机制研究”(课题号81173109),65万元人民币,2011年-2014年,主持人。
  3. 吉林省重点实验室建设项目,“吉林省重大疾病分子与化学遗传学重点实验室”建设,,40万元人民币,2010年-2012年,负责人。
  4. 973项目课题,“新的天然活性物质在脑卒中发病机理和治疗中的作用”(课题号2009CB521908),330万元人民币,2009年-2014年,课题负责人。
  5. 美国囊性纤维化基金会药物发现专项,“Discovery of Natural compounds ?F508-CFTR misprocessing correctors from Chinese medicinal herbs”(项目号MA08XX0),Cystic Fibrosis Foundation, USA. 28万美元,2008年-2010年,主持人。
  6. 国家自然科学基金,“水-甘油通道AQP3在外周神经中的表达和功能”(课题号30670477),32万元人民币,2007年-2009年,主持人。
  7. 国家自然科学基金杰出青年基金,“膜通道的结构与功能”(课题号30325011),120万元人民币,2004年-2008年,主持人。

六、发明专利

  1. “Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator inhibitor”。专利号:US 7235573B2。发明人:Alan S. Verkman,Tonghui Ma。授权时间:2007年1月26日。
  2. “HEMMER DES CFTR-PROTEINS (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE) UND IHRE VERWENDUNGEN”。专利号:EP 1549321。发明人:Alan S. Verkman,Tonghui Ma。授权时间:2005年11月8日。
  3. “嘧啶(硫)酮类化合物在制药中的应用”。发明人:麻彤辉,杨红。专利号ZL200510017135.X。授权时间:2009年2月15日。


七、发表的主要学术论文(*为通讯作者)

  1. Li GY, Li T, Fan B, Zheng YC, Ma TH*. The D(1) dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways. Mol Vis. 2012;18:2882-95. IF2.205
  2. Rasul A, Ding C, Li X, Khan M, Yi F, Ali M, Ma T*. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis. 2012 Oct; 17(10):1104-19. IF4.788
  3. Fei Y, Khan M, Gao H, Hao F, Sun M, Zhong L, Lu C, Feng X, Ma T* . Increased differentiation capacity of bone marrow-derived mesenchymal stem cells in aquaporin-5 deficiency. Stem Cells Dev. 2012 Sep 1; 21(13):2495-507. IF4.459
  4. Khan M, Yi F, Rasul A, Li T, Wang N, Gao H, Gao R, Ma T*. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life. 2012 Sep; 64(9):783-94. IF3.514
  5. Ma T*, Gao H, Fang X, Yang H. Water channel proteins in the peripheral nervous system in health and disease. Mol Asp Med. 2012 Oct; 33(5-6):605-11. IF9.97
  6. Khan M, Zheng B, Yi F, Rasul A, Gu Z, Li T, Gao H, Qazi JI, Yang H, Ma T*. ????????Pseudolaric Acid B Induces Caspase-Dependent and Caspase-Independent Apoptosis in U87 Glioblastoma Cells. Evid Based Complement Alternat Med. 2012; 2012:957568. IF4.774
  7. Xiao YH, Yang LF, Feng XC, Yang H, Ma TH*. Tanshinones Increase Fibrinolysis through Inhibition of Plasminogen Activator Inhibitor-1. CNS Neurosci Ther. 2012 May; 18(5):436-8. IF4.443
  8. Khan M, Ding C, Rasul A, Yi F, Li T, Gao H, Gao R, Zhong L, Zhang K, Fang X, Ma T*. Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells. Int. J. Biol. Sci. 2012; 8(4):533-547. IF2.699
  9. Khan M, Yu B, Rasul A, Al Shawi A, Yi F, Yang H, Ma T*. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. Evid Based Complement Alternat Med. 2012; 2012:703034. IF4.774
  10. Rasul A, Yu B, Khan M, Zhang K, Iqbal F, Ma T*, Yang H. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol. 2012 Apr; 40(4):1153-61. IF2.399
  11. Rasul A, Yu B, Zhong L, Khan M, Yang H, Ma T*. Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. Oncol Rep. 2012 May; 27(5):1481-7. IF1.835
  12. Zhu N, He C, Feng X, Ma Q, Guo L, Wang W, Yang H and Ma T*. Defective macrophage function in aquaporin-3 deficiency. Faseb J. 2011 Dec; 25(12):4233-9. ?IF5.712
  13. Li GY, Fan B, Ma TH. Visible light may directly induce nuclear DNA damage triggering the death pathway in RGC-5 cells. Mol Vis. 2011; 17:3279-89. IF2.205
  14. Yang H, Xu LN, Sui YJ, Liu X, He CY, Fang RY, Liu J, Hao F, Ma TH*. Stimulation of Airway and Intestinal Mucosal Secretion by Natural Coumarin CFTR Activators. Front Pharmacol. 2011; 2:52.
  15. Ma TH*, Gao HW, Fang XD, Yang H. Expression and function of aquaporins in peripheral nervous system. Acta Pharmacol Sin. 2011 Jun; 32(6):711-5. IF1.953
  16. Yang H, Xu LN, He CY, Liu X, Fang RY, Ma TH. CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives. Acta Pharmacol Sin. 2011 Jun; 32(6):834-9. IF1.953
  17. Sha XY, Xiong ZF, Liu HS, Zheng Z, Ma TH*. Pregnant phenotype in aquaporin 8-deficient mice. Acta Pharmacol Sin. 2011 Jun; 32(6):840-4. IF1.953
  18. Chen Q, Peng H, Lei L, Zhang Y, Kuang H, Cao Y, Shi QX, Ma T, Duan E. Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration. Cell Res. 2011 Jun; 21(6):922-33. IF8.19
  19. Su W, Qiao Y, Yi F, Guan X, Zhang D, Zhang S, Hao F, Xiao Y, Zhang H, Guo L, Yang L, Feng X, Ma T*. Increased female fertility in aquaporin 8-deficient mice. IUBMB Life. 2010 Nov; 62(11):852-7. IF3.514
  20. Guan XG, Su WH, Yi F, Zhang D, Hao F, Zhang HG, Liu YJ, Feng XC, Ma TH*. NPA motifs play a key role in plasma membrane targeting of aquaporin-4. IUBMB Life. 2010 Feb 23; 62(3): 222-226. IF3.514
  21. Liang H, Yang L, Ma T, Zhao Y. Functional Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Mouse Chondrocytes. Clin Exp Pharmacol Physiol. 2009 Oct; 37(4): 506-508. IF1.851
  22. Zhang YW, Bi LT, Hou SP, Zhao XL, Song YL, Ma TH*. Reduced Lung Water Transport Rate Associated With Down-Regulation of AQP1 and AQP5 In Aged Mice. Clin Exp Pharmacol Physiol. 2009 Jul; 36(7):734-8. IF1.851
  23. Li L, Zhang H, Verkman AS, Ma T*. Very high aquaporin-1 facilitated water permeability in mouse gallbladder. Am J Physiol Gastrointest Liver Physiol . 2009 Apr;2 96(4):G816-22. IF3.431
  24. Feng X, Papadopoulos MC, Liu J, Li L, Zhang D, Zhang H, Verkman AS, Ma T*. Sporadic obstructive hydrocephalus in Aqp4 null mice. J Neurosci Res . 2009 Apr; 87(5):1150-5. IF2.738
  25. Liu Y, Wang Y, Jiang Y, Zhu N, Liang H, Xu L, Feng X, Yang H, Ma T*. Mild processing defect of porcine DeltaF508-CFTR suggests that DeltaF508 pigs may not develop cystic fibrosis disease. Biochem Biophys Res Commun. 2008 Aug 15; 373(1):113-8. IF2. 484
  26. Xu LN, Na WL, Liu X, Hou SG, Lin S, Yang H, Ma TH*. Identification of natural coumarin compounds that rescue defective DeltaF508-CFTR chloride channel gating. Clin Exp Pharmacol Physiol . 2008 Aug; 35(8):878-83. IF1.851
  27. Liang HT, Feng XC, Ma TH*. Water channel activity of plasma membrane affects chondrocyte migration and adhesion. Clin Exp Pharmacol Physiol. 2008 Jan; 35(1):7-10. IF1. 851
  28. Wang F, Feng XC, Li YM, Yang H, Ma TH*. Aquaporins as potential drug targets. Acta Pharmacol Sin. 2006 Apr; 27(4):395-401. IF1. 953
  29. Jin SY, Liu YL, Xu LN, Jiang Y, Wang Y, Yang BX, Yang H, Ma TH*. Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system. World J Gastroenterol . 2006 Feb 21; 12(7):1092-7. IF2. 471
  30. Gao H, He C, Fang X, Hou X, Feng X, Yang H, Zhao X, Ma T*. Localization of aquaporin-1 water channel in glial cells of the human peripheral nervous system. Glia. 2006 May; 53(7):783-7. IF4.82
  31. Liu J, Shi LL, Yang H, Ma TH*. Water channels on the move: a new focus on mechanisms of cell migration and related biological processes. Prog Biochem Biophys. 2005, 32:583-586. IF0. 236
  32. Feng XC, Ma TH*. Physiological importance of aquaporin water channels accessed by phenotype studies of aquaporin knockout mice. Prog Biochem Biophys. 2005, 32:291-297. IF0. 554
  33. Binder DK, Oshio K, Ma T, Verkman AS, Manley GT. Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport. 2004 Feb 9; 15(2):259-62. IF1. 656
  34. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorg Med Chem. 2003 Sep 1; 11(18):4113-20. IF2.921
  35. Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth MJ. 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett. 2003 Aug 4; 13(15):2509-12. IF2. 554
  36. Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. J Biol Chem. 2003 Sep 12; 278(37):35079-85. IF4. 773
  37. Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L180-8. IF3.662
  38. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec; 110(11):1651-8. IF 13.069
  39. Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS. High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J Biol Chem. 2002 Oct 4; 277(40):37235-41. IF4. 773
  40. Hara M, Ma T, Verkman AS. Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity, and barrier recovery. J Biol Chem. 2002 Nov 29; 277(48):46616-21. IF4. 773
  41. Ma T*, Hara M, Sougrat R, Verbavatz JM, Verkman AS. Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. J Biol Chem. 2002 May 10; 277(19):17147-53. IF4. 773
  42. Kim YH, Earm JH, Ma T, Verkman AS, Knepper MA, Madsen KM, Kim J. Aquaporin-4 expression in adult and developing mouse and rat kidney. J Am Soc Nephrol . 2001 Sep; 12(9):1795-804. IF9.663
  43. Ma T*, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman AS. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C126-34. IF3.536
  44. Song Y, Yang B, Matthay MA, Ma T, Verkman AS. Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1744-50. IF3.536
  45. Yang B, Ma T, Verkman AS. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem. 2001 Jan 5; 276(1):624-8. IF4. 773
  46. Wang KS, Ma T, Filiz F, Verkman AS, Bastidas JA. Colon water transport in transgenic mice lacking aquaporin-4 water channels. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G463-70. IF3. 431
  47. Wang KS, Komar AR, Ma T, Filiz F, McLeroy J, Hoda K, Verkman AS, Bastidas JA. Gastric acid secretion in aquaporin-4 knockout mice. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G448-53. IF3. 431
  48. Moore M, Ma T, Yang B, Verkman AS. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res. 2000 May; 70(5):557-62. IF3. 259
  49. Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol . 2000 Jun 15;525 Pt 3:771-9. IF4. 718
  50. Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS. Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol. 2000 Jun; 278(6):C1108-15. IF3.536
  51. Verkman AS, Yang B, Song Y, Manley GT, Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000 Mar; 85 Spec No:233S-241S. IF3.211
  52. Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4386-91. IF9. 681
  53. Yang B, Ma T, Dong JY, Verkman AS. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum Gene Ther. 2000 Mar 1;11(4):567-75. IF4. 218
  54. van Hoek AN, Ma T, Yang B, Verkman AS, Brown D. Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am J Physiol Renal Physiol. 2000 Feb; 278(2):F310-6. IF3.682
  55. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000 Feb; 6(2):159-63. IF 2 2.462
  56. Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem. 2000 Jan 28; 275(4):2686-92. IF4. 773
  57. Pallone TL, Edwards A, Ma T, Silldorff EP, Verkman AS. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J Clin Invest. 2000 Jan; 105(2):215-22. IF 1 3.069
  58. Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-5 knockout mice. J Clin Invest. 2000 Jan; 105(1):93-100. IF 1 3.069
  59. Song Y, Ma T, Matthay MA, Verkman AS. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000 Jan;115(1):17-27. IF3. 841
  60. Ma T, Song Y, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem. 1999 Jul 16; 274(29):20071-4. IF4. 773
  61. Ma T, Verkman AS. Aquaporin water channels in gastrointestinal physiology. J Physiol. 1999 Jun 1; 517 ( Pt 2):317-26. IF4. 718
  62. Yang B, Ma T, Xu Z, Verkman AS. cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics. 1999 Apr 1;57(1):79-83. IF3. 019
  63. Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999 Feb;103(4):555-61. IF 1 3.069
  64. Chou CL, Knepper MA, Hoek AN, Brown D, Yang B, Ma T, Verkman AS. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest. 1999 Feb; 103(4):491-6. IF 1 3.069
  65. Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS. Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am J Physiol. 1999 Jan; 276(1 Pt 1):C76-81. IF3. 536
  66. Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, Verkman AS. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci U S A . 1998 Aug 4; 95(16):9660-4. IF9. 681
  67. Ma T, Yang B, Matthay MA, Verkman AS. Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am J Respir Cell Mol Biol. 1998 Jul; 19(1):143-9. IF5. 125
  68. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998 Feb 20; 273(8):4296-9. IF4. 773
  69. Chou CL, Ma T, Yang B, Knepper MA, Verkman AS. Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. Am J Physiol. 1998 Feb; 274(2 Pt 1):C549-54. IF3. 536
  70. Verbavatz JM, Ma T, Gobin R, Verkman AS. Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4. J Cell Sci. 1997 Nov;110 ( Pt 22):2855-60. IF6. 111
  71. Ma T, Yang B, Verkman AS. Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochem Biophys Res Commun. 1997 Nov 17; 240(2):324-8. IF2. 484
  72. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest. 1997 Sep 1; 100(5):957-62. IF1 3.069
  73. Ma T, Yang B, Umenishi F, Verkman AS. Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. Genomics. 1997 Aug 1; 43(3):387-9. IF3. 019
  74. Ma T, Yang B, Verkman AS. cDNA cloning of a functional water channel from toad urinary bladder epithelium. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1699-704. IF3. 536
  75. Ma T, Yang B, Kuo WL, Verkman AS. cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13. Genomics. 1996 Aug 1;35(3):543-50. IF3. 019
  76. Ma T, Yang B, Verkman AS. Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel. Genomics. 1996 May 1; 33(3):382-8. IF3. 019
  77. Verkman AS, van Hoek AN, Ma T, Frigeri A, Skach WR, Mitra A, Tamarappoo BK, Farinas J. Water transport across mammalian cell membranes. Am J Physiol. 1996 Jan; 270(1 Pt 1):C12-30. IF3. 536
  78. Verkman AS, Shi LB, Frigeri A, Hasegawa H, Farinas J, Mitra A, Skach W, Brown D, Van Hoek AN, Ma T. Structure and function of kidney water channels. Kidney Int. 1995 Oct; 48(4):1069-81. IF6. 606
  79. Katsura T, Verbavatz JM, Farinas J, Ma T, Ausiello DA, Verkman AS, Brown D. Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells. Proc Natl Acad Sci U S A . 1995 Aug 1; 92(16):7212-6. IF9. 681
  80. Shi LB, Skach WR, Ma T, Verkman AS. Distinct biogenesis mechanisms for the water channels MIWC and CHIP28 at the endoplasmic reticulum. Biochemistry. 1995 Jul 4; 34(26):8250-6. IF3. 422
  81. Verbavatz JM, Van Hoek AN, Ma T, Sabolic I, Valenti G, Ellisman MH, Ausiello DA, Verkman AS, Brown D. A 28 kDa sarcolemmal antigen in kidney principal cell basolateral membranes: relationship to orthogonal arrays and MIP26. J Cell Sci. 1994 Apr;107 ( Pt 4):1083-94. IF6. 111
  82. Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem. 1994 Feb 25; 269(8):5497-500. IF4. 773
  83. Ma T, Hasegawa H, Skach WR, Frigeri A, Verkman AS. Expression, functional analysis, and in situ hybridization of a cloned rat kidney collecting duct water channel. Am J Physiol. 1994 Jan; 266(1 Pt 1):C189-97. IF3. 536
  84. Ma T, Frigeri A, Skach W, Verkman AS. Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels. Biochem Biophys Res Commun. 1993 Dec 15; 197(2):654-9. IF2. 484
  85. Verbavatz JM, Brown D, Saboli? I, Valenti G, Ausiello DA, Van Hoek AN, Ma T, Verkman AS. Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. J Cell Biol. 1993 Nov; 123(3):605-18. IF10. 264
  86. Ma T, Frigeri A, Tsai ST, Verbavatz JM, Verkman AS. Localization and functional analysis of CHIP28k water channels in stably transfected Chinese hamster ovary cells. J Biol Chem. 1993 Oct 25; 268(30):22756-64. IF4.773